Wegovy Tablets (Oral Semaglutide)

Are Wegovy tablets available in the UK?

Wegovy Tablets UK. The oral form of semaglutide received FDA approval in the US in December 2025 – making it the first pill approved specifically for weight management in adults.

Wegovy Weight Loss Tablets

Medication Name	Wegovy (Semaglutide) Tablets
Medication Form	Oral tablet
Used For	Weight management in adults with obesity or overweight with at least one weight-related condition  Reducing the risk of major cardiovascular events in adults with established cardiovascular disease and obesity or overweight
Who Can Use	Adults with obesity (BMI 30 or above) or overweight (BMI 27 or above) with at least one weight-related condition such as type 2 diabetes, high blood pressure, or high cholesterol
Active Ingredient(s)	Semaglutide
Usual Dose	Starting dose: 1.5 mg once daily, escalating every 30 days to a maintenance dose of 25 mg once daily
Common Side Effects	Nausea, diarrhoea, vomiting, constipation, abdominal pain, headache, fatigue, dizziness
Prescription Required	Yes
Patient Information Leaflet	Wegovy US Prescribing Information

What are Wegovy tablets for?

Wegovy tablets are a weight loss treatment for adults who are obese or overweight and have at least one weight-related health condition, such as type 2 diabetes, high blood pressure, or high cholesterol. Taken alongside a reduced-calorie diet and increased physical activity, they are designed to help you lose weight – not as a standalone treatment. Buy Wegovy Tablets in UK, Wegovy Tablets in England, Wegovy Tablets for sale in Birmingham, Wegovy Tablets for sale in Colchester, Wegovy Tablets for sale in Oxford, Wegovy Tablets for sale in Chester UK, Buy Wegovy Tablets in  Liverpool, Buy Wegovy Tablets in Scotland, Wegovy Tablets for sale in  Wales, Wegovy Tablets in Portsmouth

Wegovy tablets are indicated for two purposes in adults:

• Weight reduction – to lose weight and reduce excess body weight long term, in adults with obesity (BMI 30 or above) or in adults with overweight (BMI 27 or above) who have at least one weight-related condition
• Cardiovascular risk reduction – to reduce the risk of serious cardiovascular events such as heart attack or stroke in adults with established cardiovascular disease and either obesity or overweight

How do Wegovy tablets work?

The Wegovy pill is an oral form of semaglutide – a GLP-1 receptor agonist. GLP-1 (glucagon-like peptide-1) is a hormone your body naturally produces after eating. Semaglutide mimics this hormone by binding to GLP-1 receptors in the brain and other organs.

This produces several effects that support weight loss:

• It reduces appetite by acting on areas of the brain that control hunger and food intake
• It slows the rate at which the stomach empties, helping you feel full for longer after eating
• It reduces the amount of food you want to eat overall

Together, these effects lead to a reduction in calorie intake, which supports long-term weight loss when combined with a healthier diet and increased activity.

In people with established cardiovascular disease, semaglutide has also been shown to reduce the risk of serious events such as heart attack and stroke, though the exact mechanism behind this cardiovascular benefit is not fully understood.

How effective are Wegovy oral pills?

Clinical trial data shows that adults taking a 25 mg Wegovy tablet daily lost around 14% of their body weight over 64 weeks, compared to 2.2% in the placebo group. Patients taking Wegovy were also significantly more likely to reach the 5%, 10%, 15% and 20% weight loss thresholds than those taking a placebo.

Weight loss varies between individuals depending on factors including starting weight, adherence to dosing instructions, and the lifestyle changes made during treatment. For the best outcome throughout your weight loss journey, Wegovy should always be used alongside a reduced-calorie diet and increased physical activity.

Who can use Wegovy tablets?

The BMI requirements for Wegovy tablets are indicated for adults with overweight or obesity who meet one of the following criteria:

• A BMI of 30 or above (obesity)
• A BMI of 27 or above (overweight) with at least one weight-related health condition, such as type 2 diabetes, high blood pressure, or high cholesterol

They are also indicated for adults with established cardiovascular disease who are obese or overweight, to reduce the risk of heart attack or stroke.

Who can’t take Wegovy tablets?

Do not use Wegovy tablets if you:

• Have a personal or family history of medullary thyroid carcinoma (MTC)
• Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
• Are allergic to semaglutide or any of the other ingredients in the tablet
• Are pregnant, or planning to become pregnant – discontinue at least 2 months before a planned pregnancy due to the long half-life of semaglutide
• Are breastfeeding

Speak to your doctor or pharmacist before using Wegovy tablets if you:

• Have a history of pancreatitis
• Have gallbladder problems or gallstones
• Have diabetic retinopathy
• Take insulin or other medicines that lower blood sugar – your doses may need to be adjusted
• Have kidney problems
• Are taking any other oral medicines – Wegovy tablets slow gastric emptying and may affect how other medicines are absorbed
• Are due to have surgery or a procedure requiring general anaesthesia or deep sedation – inform your healthcare provider, as GLP-1 receptor agonists have been associated with pulmonary aspiration in this setting
• Have type 2 diabetes – blood glucose should be monitored before and during treatment

Do not take Wegovy tablets at the same time as any other semaglutide-containing product or any other GLP-1 receptor agonist.

Wegovy Injections vs Wegovy Tablets

	Wegovy Tablet	Wegovy Injection
Active ingredient	Semaglutide	Semaglutide
Dosage	1.5 mg – 25 mg once daily	0.25 mg – 2.4 mg once weekly
How taken	Swallowed with water	Self-injected under the skin
Frequency	Once daily	Once weekly
Average weight loss	~13.6% over 64 weeks	~15% over 68 weeks
Refrigeration required	No	Yes
Approved in the UK	No	Yes

Both the Wegovy tablet and the Wegovy injection contain the same active ingredient, semaglutide and are approved for the same indications in adults. The pill version offers a daily oral option, while the weight loss injection is given once a week.

The Wegovy injection is also available in a higher-dose format – Wegovy 7.2mg – for patients who need additional weight reduction beyond the standard maintenance dose. This option is not available with the tablet.

The Wegovy pill offers a needle-free alternative to the injection, which may suit patients who prefer not to self-inject.

In terms of weight loss outcomes, the injection delivers an average body weight reduction of around 15% at the maintenance dose, compared to approximately 13.6% with the tablet over a similar timeframe. Experts generally consider this difference small and unlikely to be clinically significant for most patients. Your prescriber can help you decide which form is more appropriate for you.

Is it possible to switch from Wegovy injections to Wegovy tablets?

Switching from the Wegovy injection to the tablet is possible, but only under your prescriber’s guidance. According to US prescribing information, patients stabilised on the 2.4 mg Wegovy injection for weight reduction or cardiovascular risk reduction may switch directly to the 25 mg tablet – there is no requirement to re-escalate through the lower doses.

The recommended approach is to wait one week after your last injection before starting the 25 mg tablet once daily. Do not take both forms at the same time.

If you are considering switching, speak to your prescriber first. They will confirm if it is appropriate for you and advise on timing.

Wegovy Tablet Dosing Schedule

Wegovy tablets are started at a low dose and gradually increased over 3 months to reduce the risk of gastrointestinal side effects. The escalation schedule is as follows:

Period	Daily Dose
Days 1-30	1.5 mg
Days 31-60	4 mg
Days 61-90	9 mg
Day 91 onwards (maintenance)	25 mg

If you do not tolerate a dose increase, your prescriber may delay the escalation. The recommended maintenance dose is 25 mg once daily.

How to Take Wegovy Tablets

Taking the Wegovy pill correctly is important for absorption. Take the pill once daily, every morning, on an empty stomach. Follow these steps each time:

1. Take the pill first thing in the morning, before eating or drinking anything
2. Swallow the tablet whole with up to 4 ounces (approximately 120 ml) of water only – do not take it with any other liquid
3. Do not split, crush, chew or dissolve the tablet
4. Wait at least 30 minutes before eating food, drinking any other beverage, or taking any other oral medicines

What happens if I miss a Wegovy pill?

If you miss a dose, skip it and take your next tablet the following morning as usual. Do not take two doses on the same day to make up for a missed one.

Side Effects of Wegovy Tablets

Like all medicines, Wegovy tablets can cause side effects, though not everyone will experience them. Gastrointestinal side effects are the most common, particularly when starting treatment or after a dose increase. These often improve as your body adjusts.

Common Side Effects

These may affect more than 1 in 20 people:

• Nausea
• Diarrhoea
• Vomiting
• Constipation
• Abdominal pain
• Indigestion (dyspepsia)
• Abdominal bloating
• Burping
• Flatulence
• Gastroenteritis
• Acid reflux (gastroesophageal reflux disease)
• Headache
• Dizziness
• Fatigue
• Dysesthesia (abnormal skin sensations such as tingling or numbness)
• Hair loss
• Low blood sugar (hypoglycaemia) in people with type 2 diabetes

Serious Side Effects

Seek medical attention if you experience:

• Severe or persistent abdominal pain, with or without nausea or vomiting – this could indicate pancreatitis
• Symptoms of gallbladder problems such as upper abdominal pain, fever, or jaundice
• Signs of a serious allergic reaction, including swelling of the face, lips, tongue or throat, difficulty breathing, or a severe rash
• Signs of kidney problems, such as reduced urination or swelling in the legs
• Rapid or irregular heartbeat

Stop taking Wegovy and seek immediate medical attention if you experience signs of a serious allergic reaction (anaphylaxis or angioedema).

Wegovy Tablet Ingredients

Active ingredient: semaglutide

Other ingredients: salcaprozate sodium (SNAC), magnesium stearate

Salcaprozate sodium (SNAC) is an absorption enhancer. It protects semaglutide from being broken down by digestive enzymes in the stomach and allows it to pass into the bloodstream. This is what makes the oral tablet formulation possible. Magnesium stearate is a lubricant used during manufacturing to prevent the tablet from sticking to equipment during production.

The tablets are white to light yellow in colour. The 1.5 mg, 4 mg and 9 mg strengths are round; the 25 mg maintenance tablet is oval. All strengths are marked with the dose on one side and “novo” on the other.

Important Information

• Keep Wegovy tablets out of the sight and reach of children
• Store at room temperature between 20°C and 25°C in the original closed bottle
• Store in a dry place – keep away from moisture
• Do not store tablets in any other container
• Do not use after the expiry date shown on the packaging
• Do not use Wegovy tablets if you are pregnant or breastfeeding
• Wegovy tablets must not be taken with any other GLP-1 receptor agonist or other semaglutide-containing product at the same time
• Wegovy tablets slow gastric emptying, which can affect how other oral medicines are absorbed – always tell your doctor or pharmacist about all medicines you are taking
• If you experience sudden or severe abdominal pain, stop taking Wegovy and seek medical advice promptly – this could be a sign of pancreatitis
• Tell any surgeon, anaesthetist or healthcare professional performing a procedure that you are taking Wegovy before any planned surgery or procedure
• Heart rate may increase during treatment – your prescriber may monitor this at regular intervals
• If you have type 2 diabetes, blood glucose should be monitored before and during treatment, as your diabetes medicines may need to be adjusted

Please note: The information on this page is based on US prescribing information. Wegovy tablets are not currently available in the UK. Licensed indications may differ if approved in the UK in the future.